thermosensitive hydrogel  (Hitachi Ltd)

Journal: International Journal of Pharmaceutics: X

Article Title: Development of an injectable thermosensitive hydrogel depot system for controlled and sustained subcutaneous drug delivery

doi: 10.1016/j.ijpx.2026.100529

Figure Lengend Snippet: (A) SEM image with different magnification, (B) EDX and (C) mapping result of freeze-dried DS-loaded thermosensitive hydrogel.

Article Snippet: The optical transmittance of the thermosensitive hydrogel was determined at 450 nm using a UV–Vis spectrophotometer U-5100 (Hitachi, Tokyo, Japan).

Techniques:

Journal: International Journal of Pharmaceutics: X

Article Title: Development of an injectable thermosensitive hydrogel depot system for controlled and sustained subcutaneous drug delivery

doi: 10.1016/j.ijpx.2026.100529

Figure Lengend Snippet: (A) Dynamic swelling behavior in PBS pH = 7.4 at 25 °C and 37 °C; (B1–3) Effect of monomer, polymer, cross-linker on the swelling; (C) Effect of temperature on the swelling and (D) swelling–deswelling–reswelling cycles ability of thermosensitive hydrogels at 25 °C and 37 °C; (E1–3) Effect of monomer, polymer, cross-linker of porosity percent.

Article Snippet: The optical transmittance of the thermosensitive hydrogel was determined at 450 nm using a UV–Vis spectrophotometer U-5100 (Hitachi, Tokyo, Japan).

Techniques: Polymer

Journal: International Journal of Pharmaceutics: X

Article Title: Development of an injectable thermosensitive hydrogel depot system for controlled and sustained subcutaneous drug delivery

doi: 10.1016/j.ijpx.2026.100529

Figure Lengend Snippet: (A) In vitro biodegradation of selected hydrogels (HG-01, HG-02, and HG-06) during 10 days of incubation in lysozyme-containing PBS at 37 °C. (B) Compositional comparison of cumulative diclofenac sodium (DS) release from β-CD/CS without PNIPAM, CS-g-PNIPAM, and β-CD/CS-g-PNIPAM. (C) Temperature-dependent cumulative DS release from the optimized thermosensitive hydrogel at 25 °C and 37 °C. (D) Cumulative DS release profiles of HG-01, HG-02, and HG-06 formulations at 37 °C.

Article Snippet: The optical transmittance of the thermosensitive hydrogel was determined at 450 nm using a UV–Vis spectrophotometer U-5100 (Hitachi, Tokyo, Japan).

Techniques: In Vitro, Incubation, Comparison

Journal: International Journal of Pharmaceutics: X

Article Title: Development of an injectable thermosensitive hydrogel depot system for controlled and sustained subcutaneous drug delivery

doi: 10.1016/j.ijpx.2026.100529

Figure Lengend Snippet: (A) Assessment of the irritant potential on the HET-CAM after treatment with 0.9% NaCl (negative control), 1% SDS (positive control), and the extract solution of the thermosensitive hydrogel HG-06; (B) Evaluation of the hemocompatibility of the HG-06 thermosensitive hydrogel, with and without DS loading, by assessing its hemolytic activity in comparison with 1% Triton X-100 (positive control, 100% hemolysis) and PBS pH 7.4 (negative control, 0% hemolysis).

Article Snippet: The optical transmittance of the thermosensitive hydrogel was determined at 450 nm using a UV–Vis spectrophotometer U-5100 (Hitachi, Tokyo, Japan).

Techniques: Negative Control, Positive Control, Activity Assay, Comparison